Research by Lab

Chris Counter Molecular mechanisms underlying the evolution of normal cells into cancer

Donald Fox Extreme genome variation in organ development, repair, and disease

Sarah Goetz Cilia regulation in development and disease

Timothy Haystead Discovery and development of novel SMIs targeting purine-utilizing proteins involved in human disease

Michael Kastan Stress response pathways in mammalian cells

Cynthia Kuhn Using animal and model systems to study the biology of addiction and stress/depression

David MacAlpine Mechanisms of genetic and epigenetic inheritance

Donald McDonnell Identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers

Chris Newgard Mechanisms of metabolic regulation and fuel homeostasis in mammalian systems

Trudy Oliver Innovative approaches to combating lung cancer

Ann Marie Pendergast Tyrosine kinase signaling networks in cancer metastasis and the response to injury and regeneration

Theodore Slotkin Effects of endocrine status, environmental toxicants and drugs on brain development

Nina Tsvetanova Biochemical and spatial regulation of GPCR signaling networks and their impact on physiology

Antonius VanDongen The role of the immediate-early gene Arc in the pathophysiology of Alzheimer’s disease

G. Greg Wang Chromatin biology, human disease and therapeutics

Xiao-Fan Wang Mechanisms underlying cellular senescence and tumorigenesis

Andrew West Molecular mechanisms and genetics of neurodegeneration

Laura Wingler Why certain ligands selectively activate particular signaling pathways downstream of GPCRs

Kris Wood Novel tumor vulnerabilities and systems-based strategies to overcome therapeutic resistance

Tso-Pang Yao Biology of the histone deacetylase HDAC family and the clinical utility of HDAC inhibitors

Zhao Zhang (ZZ) Impact and regulation of transposons in both reproductive and somatic tissues

Lee Zou Principles of cellular responses to chromosomal insults and their roles in the maintenance of genomic stability