From Yeast Maps to DepMap: Conserved Principles of Genetic Interaction Networks and Insights From Biobank-Scale Human Genetics

Dr. Boone's lab develops and applies functional genomics approaches to address a variety of biological questions, including mapping genetic interaction networks in the model yeast Saccharomyces cerevisiae and human cell lines, and conducting chemical-genetic interaction screens to explore new biology and characterize therapeutically relevant compounds. The Boone lab also builds and analyzes new yeast resources, including deletion collections in genetically diverse strains, temperature-sensitive mutant libraries, and GFP-tagged mutant collections.